Nonthermal Cardiac Catheter Ablation Using Photodynamic Therapy

Nonthermal cardiac catheter ablation using photodynamic therapy.

BACKGROUND Radiofrequency ablation has limitations, largely related to creation of lesions by heating. Here, we report the first nonthermal ablation by applying photodynamic therapy (PDT) to cardiac tissues using a custom-made deflectable laser catheter. The present study investigated the feasibility of PDT for cavotricuspid isthmus ablation in a canine model. METHODS AND RESULTS We evaluated...

Catheter ablation therapy for atrial fibrillation.

Since cases were first reported in 1994, catheter ablation of atrial fibrillation has undergone rapid development and expansion. The procedure began as an attempt to recreate the Maze III operation with a catheter technique. Understanding the contribution of the pulmonary veins to the initiation and maintenance of atrial fibrillation led to dramatic changes in procedural technique. The segmenta...

Radiofrequency Catheter Ablation and Antiarrhythmic Drug Therapy

Background—Information on comparative outcome between radiofrequency catheter ablation (RFA) and antiarrhythmic drugs (AADs) 1 year after randomization is important for clinical decision-making. Methods and Results—A total of 198 patients (age, 56 10 years) with paroxysmal atrial fibrillation were randomly assigned to RFA (99 patients) or to AADs (99 patients). We evaluated efficacy of RFA or A...

Cardiac rupture following catheter ablation procedure Short Title: Cardiac rupture

Photodynamic Inactivation of Endopathogenic Microbiota Using Curcumin- mediated Antimicrobial Photodynamic Therapy

Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems. In this study, a series of experiments investigated the effects of aPDT on cell viability and biofilm degradation ability of endopathogenic mic...